E3 ubiquitin-protein ligase makorin 1, C-terminal (IPR031644)

Short name: MKRN1_C

Overlapping homologous superfamilies


Domain relationships



This domain is found at the C terminus of makorins, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs [PMID: 10843807]. Makorin-1 (MKRN1) plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT [PMID: 15805468]. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21 [PMID: 19536131]. The exact function of the C-terminal region has not been determined.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.