Domain

Sodium channel modifier 1, acidic C-terminal domain (IPR031625)

Short name: SCNM1_acidic

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the C-terminal acidic region of eukaryotic sodium channel modifier protein 1 (SCNM1). Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a [PMID: 12920299]. SCNM1 belongs to the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP [PMID: 17656373].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam