Serine/threonine-protein kinase SMG1 (IPR031559)

Short name: SMG1

Overlapping homologous superfamilies


Family relationships



Serine/threonine-protein kinase SMG1 is a phosphatidylinositol kinase-related protein that acts as an mRNA-surveillance protein and is a key component of nonsense-mediated decay (NMD) [PMID: 11331269, PMID: 15175154, PMID: 12881430, PMID: 15314158]. In C.elegans, SMG1 is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in worms [PMID: 22479207] and possibly also in higher eukaryotes.

GO terms

Biological Process

GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0016310 phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.