Domain

N-CoR, GPS2-interacting domain (IPR031557)

Short name: N-CoR_GPS2_interact

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The G-protein pathway suppressor 2 (GPS2)-interacting domain is found in NCoR (nuclear receptor corepressor) proteins. NCoR1 and NCoR2 (also known as SMRT) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways [PMID: 11931768].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam