Synaptotagmin-like mitochondrial-lipid-binding domain (IPR031468)

Short name: SMP_LBD

Overlapping homologous superfamilies


Domain relationships



This entry represents the synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in eukaryotes. The SMP domain has a beta-barrel structure like protein modules in the tubular-lipid-binding (TULIP) superfamily. It dimerises to form an approximately 90-Angstrom-long cylinder traversed by a channel lined entirely with hydrophobic residues. The following two C2 domains then form arched structures flexibly linked to the SMP domain. The SMP domain is a lipid-binding domain that links the ER with other lipid bilayer-membranes within the cell [PMID: 24847877].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008289 lipid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.