Domain

Nuclear receptor-interacting protein 1, repression domain 1 (IPR031405)

Short name: NRIP1_RD1

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 [PMID: 7641693]. It also modulates transcriptional repression by nuclear hormone receptors [PMID: 10364267] and clock gene expression [PMID: 21628546]. It consists of four distinct autonomous repression domains [PMID: 14736873].

This domain is the first (N-terminal) repression domain of nuclear receptor-interacting protein 1 [PMID: 14736873, PMID: 15060175].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam