Unique cartilage matrix-associated protein (IPR031386)

Short name: UCMA

Overlapping homologous superfamilies


Family relationships



UCMA is a secreted cartilage-specific protein expressed predominantly in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage [PMID: 18156182].

GO terms

Biological Process

GO:0045667 regulation of osteoblast differentiation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.