Domain

Bromodomain protein 4, C-terminal (IPR031354)

Short name: BRD4_CDT

Domain relationships

None.

Description

This entry represents the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II [PMID: 16109376, PMID: 21555454].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam