Domain

Cell division control protein 73, C-terminal (IPR031336)

Short name: CDC73_C

Domain relationships

None.

Description

CDC73 is an RNA polymerase II accessory factor [PMID: 8812838], and forms part of the Paf1 complex that has roles in post-initiation events [PMID: 9032243]. More specifically, crystal structure analysis shows the C terminus to be a Ras-like domain that adopts a fold that is highly similar to GTPases of the Ras superfamily. The canonical nucleotide binding pocket is altered in CDC73, and there is no nucleotide ligand, but it contributes to histone methylation and Paf1C recruitment to active genes. Thus together with Rtf1 it combines to couple the Paf1 complex to elongating polymerase [PMID: 9891041].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam