Domain

Neutral/alkaline non-lysosomal ceramidase, N-terminal (IPR031329)

Short name: NEUT/ALK_ceramidase_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes [PMID: 10753931, PMID: 10781606, PMID: 10593963]. The EC classification is (EC:3.5.1.23). The enzyme hydrolyses ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This N-terminal domain carries two metal-binding sites, the first for Zn2+ residing within the domain, and the second, for Mg2+/Ca2+ lying at the interface between the two domains [PMID: 19088069].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam