Repeat

RHS repeat (IPR031325)

Short name: RHS_repeat

Description

RHS (rearrangement hotspot) proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding [PMID: 10341219]. Note that the signature in this entry does not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain [PMID: 23913273].

The RHS repeat shares structural similarity with the eukaryotic tyrosine-aspartate (YD)-repeat [PMID: 23913273].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam