Amphoterin-induced protein (IPR031283)

Short name: AMIGO

Overlapping homologous superfamilies


Family relationships


The Amphoterin-induced protein (AMIGO) family consists of three cell surface leucine-rich repeat (LRR) proteins. AMIGO-1 is expressed on fibre tracts of neuronal tissues and participates in their formation [PMID: 12629050]. It has two other homologues, AMIGO-2, also known as DEGA (differentially expressed in human gastric adenocarcinoma) or as Alivin-1, due to its role in promoting survival of neurons, [PMID: 12843293, PMID: 15107827], and AMIGO-3, the function of which is not clear. All are thought to be cell adhesion molecules. They all have the same domain structure with an extracellular, N-terminal leucine-rich repeat (LRR) domain with six LRRs, an Ig domain, and a single transmembrane helix followed by a cytoplasmic tail.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.