Poly [ADP-ribose] polymerase 3 (IPR031275)

Short name: PARP3

Overlapping homologous superfamilies


Family relationships



PARP3 belongs to the poly-ADP-ribose polymerase (PARP) family. It plays a role in DSB (double-strand break) repair by promoting the recruitment of aprataxin-like factor (APLF) to sites of damage. It is preferentially activated by DNA breaks harbouring a 5' phosphate (5'P) [PMID: 24928857].

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins [PMID: 10455009]. PARP family members are PAR polymerases that initiate the reaction by converting the substrate nicotinamide adenine dinucleotide (NAD+) to ADP-ribose, and then catalyse ADP-ribose polymerisation on nuclear acceptor proteins [PMID: 21840394].

GO terms

Biological Process

GO:0006302 double-strand break repair
GO:0006471 protein ADP-ribosylation

Molecular Function

GO:0003950 NAD+ ADP-ribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.