Calcipressin-1 (IPR031271)

Short name: RCAN1

Family relationships


Calcipressin-1 (RCAN1, also known as DSCR1) is a calcineurin inhibitor that inactivates nuclear factor of activated T cells (NFATc) activity [PMID: 17693409]. It is expressed in the primitive ventricle of the heart and during neurogenesis [PMID: 11231093]. It is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the FLISPP motif, and this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation [PMID: 12809556]. The DSCR1 (Down syndrome critical region 1) gene is present in the region of human chromosome 21, trisomy of which is associated with congenital heart defects observed in Down syndrome [PMID: 14738882].

Calcipressins (RCANs) are a novel family of calcineurin regulators that have been suggested as key factors contributing to Down syndrome in humans. Three human calcipressins have been identified, calcipressin 1-3. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. Calcipressin 3 is also called MCIP3 and DSCR1-like 2 [PMID: 12942079]. Calcipressins contain an N-terminal RNA recognition motif (RRM), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and a C-terminal TxxP motif [PMID: 19273587].

Calcineurin is a calcium-responsive enzyme that dephosphorylates the nuclear factor of activated T cells (NFAT). In doing so, it promotes its nuclear translocation and uniquely links calcium signalling to transcriptional regulation [PMID: 12942079].

GO terms

Biological Process

GO:0033173 calcineurin-NFAT signaling cascade

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.