Transcription factor SOX-12 (IPR031267)

Short name: SOX-12

Overlapping homologous superfamilies


Family relationships


SYR-related high mobility group (HMG) box (SOX) family proteins are a conserved group of transcriptional regulators defined by the presence of a highly conserved HMG box domain that mediates DNA binding [PMID: 17584862]. SOX-12, together with SOX-4 and SOX-11, belongs to the subgroup C of the SOX gene family, with SOX-4 and SOX-11 being function redundantly with SOX-12 [PMID: 18505825, PMID: 19651233]. SOX-12 plays a critical role in embryonic development and cell-fate determination during organogenesis [PMID: 9215677, PMID: 18505825]. It has been shown to promote hepatocellular carcinoma invasion and metastasis [PMID: 25704764].

GO terms

Biological Process

GO:0045165 cell fate commitment
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0001105 RNA polymerase II transcription coactivator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.