Pathways & interactions
Transcription factor SOX-12 (IPR031267)
Short name: SOX-12
Overlapping homologous superfamilies
- Transcription factor SOX-11/4 (IPR017386)
- Transcription factor SOX-12 (IPR031267)
SYR-related high mobility group (HMG) box (SOX) family proteins are a conserved group of transcriptional regulators defined by the presence of a highly conserved HMG box domain that mediates DNA binding [PMID: 17584862]. SOX-12, together with SOX-4 and SOX-11, belongs to the subgroup C of the SOX gene family, with SOX-4 and SOX-11 being function redundantly with SOX-12 [PMID: 18505825, PMID: 19651233]. SOX-12 plays a critical role in embryonic development and cell-fate determination during organogenesis [PMID: 9215677, PMID: 18505825]. It has been shown to promote hepatocellular carcinoma invasion and metastasis [PMID: 25704764].
- PTHR10270:SF221 (PTHR10270:SF221)