Eukaryotic initiation factor 4A-I/II (IPR031258)

Short name: EIF4A1/2

Family relationships



Eukaryotic initiation factor 4A (EIF4A) consists of 3 proteins: EIF4A1, EIF4A2, and EIF4A3. They are required for the binding of mRNA to 40S ribosomal subunits. They function as ATP-dependent RNA helicases, believed to be involved in unwinding secondary structure within the 5'UTR of mRNAs, thus allowing the 40S ribosomal subunit to dock and scan toward the start codon [PMID: 19204291].

This entry includes EIF4A1 and 2. EIF4A2 interacts with components of the repression machinery and is critical for microRNA-mediated gene regulation [PMID: 23559250].

GO terms

Biological Process

GO:0006446 regulation of translational initiation

Molecular Function

GO:0004004 ATP-dependent RNA helicase activity
GO:0016887 ATPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.