Family

Gastrotropin (IPR031257)

Short name: Gastrotropin

Family relationships

Description

Gastrotropin, also known as fatty acid-binding protein 6 (FABP6) or ileal bile acid binding protein (IBABP), is an ileal protein that plays a key role in cellular trafficking and metabolic regulation of bile salts. It is able to bind to bile salts and bilirubins, and stimulates gastric acid and pepsinogen secretion. Though generally regarded as a bile acid protein, it is also capable of binding fatty acids [PMID: 12651103]. The long isoform of FABP6 is up-regulated through nuclear factor-kappaB in colorectal adenocarcinoma [PMID: 17909007].

GO terms

Biological Process

GO:0008206 bile acid metabolic process

Molecular Function

GO:0032052 bile acid binding
GO:0008289 lipid binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER