Family

Homeobox protein GBX-2 (IPR031250)

Short name: GBX-2

Family relationships

None.

Description

Gbx-2 is a homeobox protein essential for normal development of the midbrain and the anterior hindbrain [PMID: 8652408, PMID: 11900984, PMID: 9767156]. It functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner [PMID: 23933069].

The homeobox domain (homeodomain) is a 60-residue motif first identified in a number of Drosophila homeotic and segmentation proteins, but now known to be well-conserved in many other animals, including vertebrates [PMID: 1357790, PMID: 2568852]. Proteins containing homeobox domains are likely to play an important role in development - most are known to be sequence-specific DNA-binding transcription factors. The domain binds DNA through a helix-turn-helix (HTH) structure.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER