Homeobox protein GBX-2 (IPR031250)

Short name: GBX-2

Overlapping homologous superfamilies


Family relationships



Gbx-2 is a homeobox protein essential for normal development of the midbrain and the anterior hindbrain [PMID: 8652408, PMID: 11900984, PMID: 9767156]. It functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner [PMID: 23933069].

The homeobox domain (homeodomain) is a 60-residue motif first identified in a number of Drosophila homeotic and segmentation proteins, but now known to be well-conserved in many other animals, including vertebrates [PMID: 1357790, PMID: 2568852]. Proteins containing homeobox domains are likely to play an important role in development - most are known to be sequence-specific DNA-binding transcription factors. The domain binds DNA through a helix-turn-helix (HTH) structure.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.