Family

RNF213 protein (IPR031248)

Short name: RNF213

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

RNF213 functions as ubiquitin ligase and AAA+ ATPase, and plays a role in vascular development through mechanical processes in the cell [PMID: 24658080]. It contains a RING finger domain, which is a well-established ubiquitin ligase domain that covalently modifies substrate proteins with ubiquitin and stimulates the proteasomal protein degradation. It also functions as an ATPase through its AAA+ ATPase modules [PMID: 24658080]. The RNF213 gene is a susceptibility gene for moyamoya disease, an idiopathic vascular disorder of intracranial arteries [PMID: 21799892].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016887 ATPase activity
GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER