Unconventional myosin-XVIIIa (IPR031244)

Short name: MYO18A

Overlapping homologous superfamilies


Family relationships



Myosin-XVIIIa (MYO18A) is a unique PDZ domain-containing unconventional myosin conserved from Drosophila to vertebrates. Unlike conventional myosins, it has weak ATP-insensitive actin binding ability and does not act as actively translocating motor [PMID: 23382379, PMID: 15835906]. Golgi protein GOLPH3 binds to MYO18A, and this interaction has been suggested to provide the link between Golgi and F-actin [PMID: 19837035]. MYO18A may also function in the adhesion process that maintains the stable attachment of myofibres to ECM (extracellular matrix) and muscle integrity during early development [PMID: 25160974].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051015 actin filament binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.