ATP-binding cassette sub-family D member 3 (IPR031241)

Short name: ABCD3

Overlapping homologous superfamilies


Family relationships


The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

ATP-binding cassette sub-family D member 3 (ABCD3, also known as PMP70) is a half ATP binding cassette (ABC) transporter found in the peroxisome membrane [PMID: 11248239]. It can function as a homodimer and is involved in the peroxisomal import of a range of unsaturated and dicarboxylic fatty acids [PMID: 24333844].

GO terms

Biological Process

GO:0015910 long-chain fatty acid import into peroxisome

Molecular Function

GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042803 protein homodimerization activity

Cellular Component

GO:0005777 peroxisome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.