ATP-binding cassette sub-family D member 3 (IPR031241)
Short name: ABCD3
Overlapping homologous superfamilies
- Peroxysomal long chain fatty acyl transporter (IPR005283)
- ATP-binding cassette sub-family D member 3 (IPR031241)
The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].
ATP-binding cassette sub-family D member 3 (ABCD3, also known as PMP70) is a half ATP binding cassette (ABC) transporter found in the peroxisome membrane [PMID: 11248239]. It can function as a homodimer and is involved in the peroxisomal import of a range of unsaturated and dicarboxylic fatty acids [PMID: 24333844].
- PTHR11384:SF34 (PTHR11384:SF34)