Cullin-9 (IPR031222)

Short name: CUL9

Overlapping homologous superfamilies


Family relationships



Cullin-9, also known as PARC, is a core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of survivin (BIRC5), an inhibitor of apoptosis protein. It is a critical downstream effector of the 3M complex (consisting of CUL7, OBSL1 and CCDC8) in the maintenance of microtubules and genome integrity [PMID: 24793696]. It also regulates the subcellular localisation of p53/TP53 and subsequent function [PMID: 12526791, PMID: 17332328].

GO terms

Biological Process

GO:0000226 microtubule cytoskeleton organization
GO:0016567 protein ubiquitination
GO:0007088 regulation of mitotic nuclear division

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031461 cullin-RING ubiquitin ligase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.