XIAP-associated factor 1 (IPR031220)

Short name: XAF1

Overlapping homologous superfamilies


Family relationships



XAF1 (X-linked inhibitor of apoptosis (XIAP)-associated factor 1) is a proapoptotic protein that antagonises the caspase-inhibitory activity of XIAP [PMID: 11175744, PMID: 17329253]. It is a tumor suppressor that is frequently inactivated in many human cancers. It forms a positive feedback loop with p53 and acts as a molecular switch in p53-mediated cell-fate decisions favoring apoptosis over cell-cycle arrest [PMID: 25313037].

GO terms

Biological Process

GO:0006915 apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.