Interferon regulatory factor 1 (IPR031215)

Short name: IRF1

Overlapping homologous superfamilies


Family relationships


Interferon regulatory factor 1 (IRF1) is a transcriptional regulator involved in the regulation of several cellular responses, such as regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage [PMID: 15226432, PMID: 11244049, PMID: 22200613, PMID: 19851330, PMID: 15509808, PMID: 11846974].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0050776 regulation of immune response
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.