Myocilin (IPR031213)

Short name: Myocilin

Overlapping homologous superfamilies


Family relationships



Myocilin is a secreted glycoprotein that belongs to the family of olfactomedin domain-containing proteins. Myocilin regulates different signalling pathways that control processes such as cell adhesion [PMID: 18855004], cytoskeleton organisation [PMID: 19188438] and cell migration [PMID: 21656515]. It is highly expressed in ocular drainage structures, such as the trabecular meshwork, which is responsible for a maintaining proper balance of intraocular pressure [PMID: 17516541]. Myocilin mutations are linked to glaucoma [PMID: 19959812].

GO terms

Biological Process

GO:0030335 positive regulation of cell migration
GO:0001952 regulation of cell-matrix adhesion
GO:0051492 regulation of stress fiber assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.