Peptidyl-prolyl cis-trans isomerase FKBP4 (IPR031212)

Short name: FKBP4

Overlapping homologous superfamilies


Family relationships


FKBP4 (also known as FKBP52) is an immunophilin that binds immunosuppressive drugs such as FK506 [PMID: 18635947]. It interacts with Hsp90 [PMID: 20188096] and has been shown to have peptidyl prolyl cis/trans isomerase activity [PMID: 11350175]. It controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening [PMID: 19945390].

GO terms

Biological Process

GO:0000413 protein peptidyl-prolyl isomerization

Molecular Function

GO:0005528 FK506 binding
GO:0031072 heat shock protein binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.