Nestin (IPR031211)

Short name: Nestin

Overlapping homologous superfamilies


Family relationships


Nestin is an intermediate filament protein. However, nestin cannot form homodimers to form intermediate filaments due to its short N-terminal; it can only form heterodimers and heterotetramers by binding with other intermediate filament proteins, particularly the class 3 proteins vimentin and alpha-internexin [PMID: 18197384]. It is believed to be a neural stem cell marker during central nervous system (CNS) development [PMID: 18197384, PMID: 7720210, PMID: 20963821], although it is also expressed in other tissues [PMID: 25970547, PMID: 25500739]. Nestin has been found to be involved in tumour angiogenesis [PMID: 25164879, PMID: 25940879].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019215 intermediate filament binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.