PHD finger protein 1 (IPR031202)

Short name: PHF1

Overlapping homologous superfamilies


Family relationships



PHD finger protein 1 (PHF1) is a polycomb group (PcG) protein that plays a role in H3K27 methylation and Hox gene silencing [PMID: 18086877]. The Tudor domain of human PHF1 recognises both H3K36me3 and H3tK27me3 [PMID: 23954330, PMID: 23142980]. The interaction between PHF1 and H3K36me3 stabilises the nucleosome in a conformation in which the nucleosomal DNA is more accessible to DNA-binding regulatory proteins [PMID: 24352064]. PHF1 is also involved in the response to DNA double-strand breaks [PMID: 18385154] and acts as a positive regulator of the p53 pathway [PMID: 23150668].

GO terms

Biological Process

GO:0006974 cellular response to DNA damage stimulus
GO:0031060 regulation of histone methylation

Molecular Function

GO:0035064 methylated histone binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.