MAGUK p55 subfamily member 5 (IPR031185)

Short name: MPP5

Overlapping homologous superfamilies


Family relationships



Membrane-associated guanylate kinase (MAGUK) p55 subfamily member 5 (MPP5, also known as PALS1 or Stardust in Drosophila) plays a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells [PMID: 15677456, PMID: 25385611]. Zebrafish MPP5A is essential for cellular patterning of the retina [PMID: 11992120].

The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains [PMID: 11414766]. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [PMID: 17678554].

GO terms

Biological Process

GO:0070830 bicellular tight junction assembly
GO:0090162 establishment of epithelial cell polarity

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.