Antizyme inhibitor 1 (IPR031178)

Short name: Azin1

Overlapping homologous superfamilies

Family relationships


Antizymes (AZs) are polyamine-induced proteins that promote degradation of ornithine decarboxylase (ODC), the key enzyme in the polyamine biosynthetic pathway [PMID: 8848835]. AZs also negatively regulate polyamine transport into the cells through an unknown mechanism [PMID: 8166639]. AZs are in turn regulated by antizyme inhibitors (AZIN1 and AZIN2), which are proteins homologous to ODC that bind to AZs and counteract their negative effect on ODC [PMID: 24967154].

AZIN1 is expressed in most tissues of mouse and participates in polyamine metabolism and cell growth [PMID: 22562773]. AZIN1 is induced by various proliferative stimuli and repressed by polyamines, forming a negative feedback loop [PMID: 24077669].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0042978 ornithine decarboxylase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.