Antizyme inhibitor 2 (IPR031173)

Short name: Azin2

Overlapping homologous superfamilies

Family relationships


Antizymes (AZs) are polyamine-induced proteins that promote degradation of ornithine decarboxylase (ODC), the key enzyme in the polyamine biosynthetic pathway [PMID: 8848835]. AZs also negatively regulate polyamine transport into the cells through an unknown mechanism [PMID: 8166639]. AZs are in turn regulated by antizyme inhibitors (AZIN1 and AZIN2), which are proteins homologous to ODC that bind to AZs and counteract their negative effect on ODC [PMID: 24967154].

Antizyme inhibitor 2 (AZIN2) affects polyamine homeostasis not only by increasing ODC activity, but also by stimulating polyamine uptake [PMID: 18062773, PMID: 24967154]. AZIN2 may have a role in spermiogenesis [PMID: 18973822, PMID: 19956990].

GO terms

Biological Process

GO:1902269 positive regulation of polyamine transmembrane transport

Molecular Function

GO:0042978 ornithine decarboxylase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.