Active Site

Glycosyl hydrolases family 10, active site (IPR031158)

Short name: GH10_AS

Description

The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases (EC:3.2.1.4), cellobiohydrolases (EC:3.2.1.91) (exoglucanases), or xylanases (EC:3.2.1.8) [PMID: 2252383, PMID: 1886523]. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family F [PMID: 2806912] or as the glycosyl hydrolases family 10 [PMID: 1747104].

This entry represents one of the conserved regions in these enzymes, which is centred on a conserved glutamic acid residue that has been shown [PMID: 1678739], in the exoglucanase from Cellulomonas fimi, to be directly involved in glycosidic bond cleavage by acting as a nucleophile.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns