BBP/SF1 family (IPR031150)

Short name: BBP/SF1

Overlapping homologous superfamilies

Family relationships



BBP/SF1 family members include the branchpoint binding proteins (BBP) from yeast and their mammalian homologue, splicing factor 1 (SF1). They are KH domain containing proteins required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [PMID: 12374752, PMID: 10775271]. In budding yeasts, BBP binds the conserved RNA sequence UACUAAC, called the branchpoint motif, found near the 3' end of yeast introns [PMID: 21189690]. Besides its function in pre-mRNA splicing, BBP is also involved in nuclear retention of pre-mRNA [PMID: 10775271]. Mammalian SF1, also known as ZFM1, may act as transcription repressor [PMID: 9660765].

GO terms

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

GO:0003723 RNA binding
GO:0045131 pre-mRNA branch point binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.