Family

BRCA1-associated (IPR031099)

Short name: BRCA1-associated

Family relationships

Description

This entry includes animal BRCA1 (BREAST CANCER SUSCEPTIBILITY 1) proteins and their homologues from plants [PMID: 22629260].

The aimal BRCA1 protein is a E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage [PMID: 10500182, PMID: 10724175]. It contains an N-terminal zinc-finger domain. It also contains a BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PMID: 14576433].

Arabidopsis BRCA1-related proteins includes AtBRCA1(AT4G21070, Q8RXD4) and AtBARD1 (AT1G04020, F4I443). Both are involved in DNA repair in plants [PMID: 16957774, PMID: 25527727]. AtBRCA1 can be induced by gamma-rays [PMID: 12582233]. AtBARD1, also known as Row1, functions mainly as a REPRESSOR OF WUSCHEL1, which is a transcription repressor required to regulate the maintenance of stem cell populations in shoot meristems [PMID: 19704708, PMID: 25631790].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER