Serine/threonine-protein phosphatase 4 regulatory subunit 1 (IPR031087)

Short name: PP4R1

Overlapping homologous superfamilies

Family relationships



PP4R1 is a regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). The catalytic subunit of PP4 (PP4C) belongs to the PP2A family of serine/threonine protein phosphatases [PMID: 9325055]. Although 65% identical to the catalytic subunit of PP2AC, PP4C does not associate with the regulatory subunit of PP2A. Instead, PP4C associates with two other regulatory subunits, PP4R1 [PMID: 10026142] and PP4R2 [PMID: 10769191].

PP4R1 targets TRAF2 and TRAF6 to mediate inhibition of NF-kB activation [PMID: 25134449].

GO terms

Biological Process

GO:0050790 regulation of catalytic activity
GO:0007165 signal transduction

Molecular Function

GO:0019888 protein phosphatase regulator activity

Cellular Component

GO:0030289 protein phosphatase 4 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.