OTU domain-containing protein 5/Otubain-like deubiquitinase 1 (IPR031084)

Short name: OTU5/OTLD1

Overlapping homologous superfamilies


Family relationships



Proteins in this entry are deubiquitinases, including OTUD5 (OTU domain-containing protein 5) from animals and otubain-like deubiquitinase 1 (OTLD1, AT2G27350, Q9XIP2) from Arabidopsis. Human OTUD5, also known as DUBA, functions as negative regulator of the innate immune system [PMID: 17991829, PMID: 22245969] and is a post-translational suppressor of IL-17 production in T cells [PMID: 25470037]. Arabidopsis OTLD1 is involved in transcriptional gene repression via histone deubiquitination and demethylation [PMID: 21690391].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.