High mobility group protein HMGA1, mammal (IPR031079)

Short name: HMGA1_mammal

Overlapping homologous superfamilies


Family relationships


This entry represents HMGA1 from mammals. Overexpression of HMGA1 correlates with the malignant status and prognosis of cancers [PMID: 25772486, PMID: 25586095, PMID: 23658826].

The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [PMID: 25281808].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.