High mobility group protein HMGB3 (IPR031077)

Short name: HMGB3

Overlapping homologous superfamilies


Family relationships



This entry represents HMGB3. It regulates the balance between hematopoietic stem cell self-renewal and differentiation [PMID: 16945912]. It also inhibits myeloid and B-cell differentiation [PMID: 12714519]. Overexpression of HMGB3 promotes cell proliferation, migration and is associated with poor prognosis of cancers [PMID: 25647262, PMID: 25755721].

The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [PMID: 25281808].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.