High mobility group protein HMGN3 (IPR031073)

Short name: HMGN3

Overlapping homologous superfamilies


Family relationships


HMGN3 belongs to the HMGN family, whose members promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates [PMID: 21278158]. HMGNs are expressed only in vertebrates [PMID: 25281808]. HMGN3 is highly expressed in the eye and in the brain, where it might play a role in astrocyte function [PMID: 25281808]. In adult pancreatic islet cells, HMGN3 affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion [PMID: 19651901].

The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [PMID: 25281808].

GO terms

Biological Process

GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus

Molecular Function

GO:0003682 chromatin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.