Ribosome-releasing factor 2, mitochondrial (IPR030851)

Short name: EFG2

Overlapping homologous superfamilies


Family relationships



Bacterial translation elongation factor G (EF-G) catalyses translocation during peptide elongation and mediates ribosomal disassembly during ribosome recycling with the aid of the ribosomal recycling factor (RRF). Human mitochondria contains two EF-G homologues, EF-G1 and EF-G2. This entry represents EF-G2, also known as ribosome-releasing factor 2 (RRF2), which mediates ribosome recycling with human mitochondrial RRF, but lacks translocation activity [PMID: 19716793]. This entry also includes EFG2 homologues from other animals and fungi. Its budding yeast homologue, known as Mef2, is required for respiratory growth and is essential for mitochondrial genome maintenance [PMID: 7483851, PMID: 21414316].

GO terms

Biological Process

GO:0032790 ribosome disassembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.