Ubiquitin carboxyl-terminal hydrolase 16 (IPR030849)

Short name: UBP16

Overlapping homologous superfamilies

Family relationships



Ubiquitin carboxyl-terminal hydrolase 16 (UBP16 or Ubp-M), also known as ubiquitin-specific protease 16 (USP16), is a histone H2A deubiquitinase required for cell cycle M phase progression. It also regulates gene expression in G1/S phase. In Xenopus embryos, it regulates embryonic anterior-posterior patterning through the regulation of Hox gene expression [PMID: 17914355]. USP16 is a critical regulator of DNA damage response that fine-tunes DNA damage-induced histone ubiquitin foci formation [PMID: 25305019].

GO terms

Biological Process

GO:0016578 histone deubiquitination
GO:0051726 regulation of cell cycle
GO:0010468 regulation of gene expression

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.