Mitochondrial glycine transporter Hem25/SLC25A38 (IPR030847)

Short name: Hem25/SLC25A38

Overlapping homologous superfamilies

Family relationships


This entry includes a group of mitochondrial glycine transporters, including Hem25 from budding yeasts and SLC25A38 from humans. They transport glycine into mitochondria for initiation of heme biosynthesis [PMID: 27476175].

Solute carrier family 25 member 38 (SLC25A38) belongs to the SLC25 family, whose members are inner mitochondrial membrane transporters promoting the exchange of one metabolite for another across the inner mitochondrial membrane. Mutations in the SLC25A38 gene cause nonsyndromic autosomal recessive congenital sideroblastic anemia [PMID: 19412178, PMID: 21393332].

GO terms

Biological Process

GO:1904983 glycine import into mitochondrion

Molecular Function

GO:0015187 glycine transmembrane transporter activity

Cellular Component

GO:0005743 mitochondrial inner membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.