Family

Endonuclease III-like protein 1 (IPR030841)

Short name: NTH1

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry includes human endonuclease III-like protein 1 (NTH1) and its homologues from animals, yeasts and plants. NTH1 is a bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary pathway for the repair of oxidative DNA damage [PMID: 21930793]. In budding yeasts it is also known as Ntg1, which has an a paralogue, Ntg2 [PMID: 14500818]. Yeast Ntg1 creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress [PMID: 19074198].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0006285 base-excision repair, AP site formation

Molecular Function

GO:0019104 DNA N-glycosylase activity
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP