Pathways & interactions
Cardiolipin synthase A (IPR030840)
Short name: CL_synthase_A
Overlapping homologous superfamilies
- Cardiolipin synthase (IPR022924)
- Cardiolipin synthase A (IPR030840)
Most bacteria use an enzyme belonging to the phospholipase D family as cardiolipin synthase. In contrast, eukaryotes and most actinobacteria use a cardiolipin synthase of the CDP-alcohol phosphatidyltransferase family [PMID: 19439403].
This entry represents the ClsA sub-subfamily of cardiolipin synthases that belong to the phospholipase D family. These proteins catalyse the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (diphosphatidylglycerol) and glycerol [PMID: 9370333]. Bacillus subtilis has three genes (clsA, ywjE and ywiE) for CL synthase; the main role in CL synthesis being played by clsA [PMID: 14973018].
- MF_00190 (Cardiolipin_synth_ClsA)