Cardiolipin synthase A (IPR030840)

Short name: CL_synthase_A

Overlapping homologous superfamilies


Family relationships


Most bacteria use an enzyme belonging to the phospholipase D family as cardiolipin synthase. In contrast, eukaryotes and most actinobacteria use a cardiolipin synthase of the CDP-alcohol phosphatidyltransferase family [PMID: 19439403].

This entry represents the ClsA sub-subfamily of cardiolipin synthases that belong to the phospholipase D family. These proteins catalyse the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (diphosphatidylglycerol) and glycerol [PMID: 9370333]. Bacillus subtilis has three genes (clsA, ywjE and ywiE) for CL synthase; the main role in CL synthesis being played by clsA [PMID: 14973018].

GO terms

Biological Process

GO:0032049 cardiolipin biosynthetic process

Molecular Function

GO:0008808 cardiolipin synthase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.