Family

Microtubule-associated protein 2 (IPR030797)

Short name: MAP2

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Microtubule-associated protein 2 (MAP2) is a microtubule-associated protein involved in microtubule assembly and stability. It binds to the SH3 domains of c-Src and Grb2, and may serve as a molecular scaffold upon which cytoskeleton-modifying proteins assemble and dissociate in response to neuronal activity [PMID: 10781592]. In humans MAP2 has several isoforms resulting from alternative splicing of a single gene. One of the isoform, MAP-2c, can directly recruit multiple signaling proteins important for central nervous system development [PMID: 15536091].

GO terms

Biological Process

GO:0021954 central nervous system neuron development
GO:0001578 microtubule bundle formation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER