Islet cell autoantigen 1 (IPR030796)

Short name: ICA1

Overlapping homologous superfamilies


Family relationships


Islet cell autoantigen 69 kDa (ICA69) or islet cell autoantigen 1 was identified with a group of type 1 diabetes-related islet autoantigens [PMID: 8326004]. ICA69 is enriched in the Golgi complex, and its N-terminal half contains a BAR-domain [PMID: 18187231]. ICA69 forms heteromeric BAR-domain complexes with another cytosolic lipid-binding protein, PICK1. Together they are key regulators of the formation and maturation of insulin granules [PMID: 23630453].

GO terms

Biological Process

GO:0050796 regulation of insulin secretion

Molecular Function

GO:0019904 protein domain specific binding

Cellular Component

GO:0000139 Golgi membrane
GO:0030667 secretory granule membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.