Protein sprouty homologue 4 (IPR030790)

Short name: SPRY4

Overlapping homologous superfamilies


Family relationships

  • Sprouty (IPR007875)
    • Protein sprouty homologue 4 (IPR030790)


Protein sprouty homologue 4 (SPRY4) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY4 is a feedback negative regulator of FGFs-induced ERK1/2 signalling. It suppresses Ras-independent ERK activation by binding to Raf1 [PMID: 12717443]. It may function as a tumour suppressor in endometrial adenocarcinoma [PMID: 24811094]. It plays a critical role in developing inflammatory Th17 cells in Th17 cell-driven autoimmune diseases [PMID: 24732356].

GO terms

Biological Process

GO:0070373 negative regulation of ERK1 and ERK2 cascade

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.