Protein sprouty homologue 1 (IPR030783)

Short name: SPRY1

Overlapping homologous superfamilies


Family relationships

  • Sprouty (IPR007875)
    • Protein sprouty homologue 1 (IPR030783)


Protein sprouty homologue 1 (SPRY1) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY1 has been implicated with tumorigenesis of different types of cancers [PMID: 24510305, PMID: 24270409].

GO terms

Biological Process

GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0046580 negative regulation of Ras protein signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0001759 organ induction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.