Protein sprouty homologue 2 (IPR030780)

Short name: SPRY2

Overlapping homologous superfamilies


Family relationships

  • Sprouty (IPR007875)
    • Protein sprouty homologue 2 (IPR030780)


Protein sprouty homologue 2 (SPRY2) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases [PMID: 17974561]. SPRY2 functions as a negative regulator of receptor tyrosine kinase/ERK signaling pathway and is involved in many biological processes, including cell growth, differentiation, migration, and embryonic lung branching morphogenesis [PMID: 25399781, PMID: 17516543]. It inhibits FGF-RAS-ERK signaling by binding to growth factor receptor bound protein 2 (GRB2) during fibroblast growth factor receptor (FGFR) activation, disrupting the GRB2-SOS (son of sevenless) complex that transduces signals from FGFR to RAS [PMID: 24469046, PMID: 12402043].

GO terms

Biological Process

GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0046580 negative regulation of Ras protein signal transduction
GO:0045595 regulation of cell differentiation
GO:0042127 regulation of cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.