Regulator of G-protein signalling 14 (IPR030776)

Short name: RGS14

Overlapping homologous superfamilies


Family relationships



RGS14 is a regulator of G protein signaling (RGS) protein. It regulates G protein nucleotide exchange and hydrolysis by acting as a GTPase-activating protein (GAP) through its RGS domain, and as a guanine nucleotide dissociation inhibitor (GDI) through its GoLoco motif [PMID: 10606204, PMID: 11387333]. Both domains of RGS14 target members of the Gialpha subclass [PMID: 17635935]. It is a microtubule-associated protein that may modulate microtubule dynamics and spindle formation [PMID: 15917656] and play an essential role during mammalian cell division [PMID: 17635935]. RGS14 regulates the activation of alphaMbeta2 integrin during phagocytosis [PMID: 23805333]. It is a key regulator of signalling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory [PMID: 20837545].

GO terms

Biological Process

GO:0051301 cell division
GO:0035556 intracellular signal transduction
GO:0007051 spindle organization

Molecular Function

GO:0001965 G-protein alpha-subunit binding
GO:0005092 GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0008017 microtubule binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.